A LOW MOLECULAR WEIGHT HEPARIN INHIBITS EXPERIMENTAL METASTASIS IN MICE INDEPENDENTLY OF THE ENDOTHELIAL GLYCOCALYX.

A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx.

BACKGROUND: Some low molecular weight heparins (LMWHs) prolong survival of cancer patients and inhibit experimental metastasis.The underlying mechanisms are still not clear but it has been suggested that LMWHs (at least in part) limit metastasis by preventing cancer cell-induced destruction of the endothelial glycocalyx.METHODOLOGY/PRINCIPAL FINDIN

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Genomic signatures of local directional selection in a high gene flow marine organism; the Atlantic cod (Gadus morhua)

Abstract Background Marine fishes have been shown to display low levels of genetic structuring and associated high levels of gene flow, suggesting shallow evolutionary trajectories and, possibly, limited or lacking adaptive divergence among local populations.We investigated variation in 98 gene-associated single nucleotide polymorphisms (SNPs) for

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